Young genes are essential too

Are you too young?

At a time when the value of performing aortic valve replacement surgery on elderly patients with aortic stenosis (AS) was being questioned, we reported our findings of a formal decision analysis entitled “You’re Never Too Old” (1) that revealed survival benefit of surgical aortic valve replacement (SAVR) in symptomatic elderly AS patients. SAVR is currently widely accepted as a treatment of oth...

Why are essential genes essential? - The essentiality of Saccharomyces genes

Essential genes are defined as required for the survival of an organism or a cell. They are of particular interests, not only for their essential biological functions, but also in practical applications, such as identifying effective drug targets to pathogenic bacteria and fungi. The budding yeast Saccharomyces cerevisiae has approximately 6,000 open reading frames, 15 to 20% of which are deeme...

Too much too young? In Nepal more a case of too little, too young.

Too much too young? In Nepal more a case of too little, too young Sally Sm ith Director Sakn ya HIV/ AIDS Preven tion Edu cation Un it, Un ited Mission s to Nepal (u n til 1999).

Thrombolysis: too old and too young.

RESEARCH ARTICLES How Essential Are Nonessential Genes?

Gene essentiality in bacteria has been identified in silico, focusing on gene persistence, or experimentally, focusing on the growth of knockouts in rich media. Comparing 55 genomes of Firmicutes and Gamma-proteobacteria to identify the genes which, while persistent among genomes, do not lead to a lethal phenotype when inactivated, we show that the characteristics of persistence, conservation, ...